The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair

A Syed, JA Tainer - Annual review of biochemistry, 2018 - annualreviews.org
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …

Mechanisms of ATM activation

TT Paull - Annual review of biochemistry, 2015 - annualreviews.org
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

L Bian, Y Meng, M Zhang, D Li - Molecular Cancer, 2019 - Springer
Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular
responses to DNA damage. This feature of malignant cells opens new avenues for tumor …

Relationship between the architecture of zinc coordination and zinc binding affinity in proteins–insights into zinc regulation

T Kochańczyk, A Drozd, A Krężel - Metallomics, 2015 - academic.oup.com
Zinc proteins are an integral component of the proteome of all domains of life. Zn (ii), one of
the most widespread transition elements, serves multiple functions in proteins, such as a …

Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis

D Su, S Ma, L Shan, Y Wang, Y Wang… - The Journal of …, 2018 - Am Soc Clin Investig
Central to the recognition, signaling, and repair of DNA double-strand breaks (DSBs) are the
MRE11-RAD50-NBS1 (MRN) complex and mediator of DNA damage checkpoint protein 1 …

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

JMD Legrand, AL Chan, HM La, FJ Rossello… - Nature …, 2019 - nature.com
Mammalian spermatogenesis is sustained by mitotic germ cells with self-renewal potential
known as undifferentiated spermatogonia. Maintenance of undifferentiated spermatogonia …

Role of the Mre11 complex in preserving genome integrity

J Oh, LS Symington - Genes, 2018 - mdpi.com
DNA double-strand breaks (DSBs) are hazardous lesions that threaten genome integrity and
cell survival. The DNA damage response (DDR) safeguards the genome by sensing DSBs …

[HTML][HTML] Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair

J Lafrance-Vanasse, GJ Williams, JA Tainer - Progress in biophysics and …, 2015 - Elsevier
Abstract The Mre11-Rad50-Nbs1 (MRN) complex is a dynamic macromolecular machine
that acts in the first steps of DNA double strand break repair, and each of its components has …

Challenges and perspectives in homology-directed gene targeting in monocot plants

T Van Vu, YW Sung, J Kim, DTH Doan, MT Tran… - Rice, 2019 - Springer
Continuing crop domestication/redomestication and modification is a key determinant of the
adaptation and fulfillment of the food requirements of an exploding global population under …

[HTML][HTML] Structural zinc binding sites shaped for greater works: Structure-function relations in classical zinc finger, hook and clasp domains

M Padjasek, A Kocyła, K Kluska, O Kerber… - Journal of Inorganic …, 2020 - Elsevier
Metal ions are essential elements present in biological systems able to facilitate many
cellular processes including proliferation, signaling, DNA synthesis and repair. Zinc ion (Zn …