Co-trimoxazole is an inexpensive, broad-spectrum antimicrobial drug that is widely used in
developing countries. Before antiretroviral therapy (ART) scale-up, co-trimoxazole …

Malaria, a parasite vector-borne disease, is one of the most significant health threats in
tropical regions, despite the availability of individual chemoprophylaxis. Malaria …

Background Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–
pyrimethamine (SP) is widely implemented in sub-Saharan Africa for the prevention of …

Malaria infection during pregnancy is an important driver of maternal and neonatal health in
endemic countries. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine …

Background Malaria and HIV infection overlap geographically in sub‐Saharan Africa and
share risk factors. HIV infection increases malaria's severity, especially in pregnant women …

Background The safety profile of antimicrobials used during pregnancy is one important
consideration in the decision on how to treat and provide postexposure prophylaxis (PEP) …

Introduction: Over 100 million women and their babies are at risk of malaria in pregnancy
each year. Malaria prevention in pregnancy relies on long-lasting insecticidal nets (LLINs) …

Background It is known that antimalarial drugs reduce the risk of low birth weight (LBW) in
pregnant patients. However, a previous Cochrane review did not evaluate whether the level …

Background Drug safety assessments in clinical trials present unique analytical challenges.
Some of these include adjusting for individual follow-up time, repeated measurements of …

Aims Data available on the fetal safety of trimethoprim–sulfamethoxazole (TMP‐SMX)
exposure during pregnancy remains scarce and inconclusive. A previous study assessing …