Tight junctions of the outer blood retina barrier
A Naylor, A Hopkins, N Hudson… - International journal of …, 2019 - mdpi.com
The outer blood retina barrier (oBRB) formed by the retinal pigment epithelium (RPE) is
critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is …
critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is …
Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier
MA Fields, LV Del Priore, RA Adelman… - Progress in retinal and …, 2020 - Elsevier
The three interacting components of the outer blood-retinal barrier are the retinal pigment
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …
Retinal pigment epithelium polarity in health and blinding diseases
PS Caceres, E Rodriguez-Boulan - Current opinion in cell biology, 2020 - Elsevier
The polarized phenotype of the retinal pigment epithelium is crucial for the outer retina-
blood barrier and support of photoreceptors and underlying choroid, and its disruption plays …
blood barrier and support of photoreceptors and underlying choroid, and its disruption plays …
Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue
A Rodrigues, A Slembrouck-Brec, C Nanteau… - NPJ Regenerative …, 2022 - nature.com
Mutations in the ubiquitously expressed pre-mRNA processing factor (PRPF) 31 gene, one
of the most common causes of dominant form of Retinitis Pigmentosa (RP), lead to a retina …
of the most common causes of dominant form of Retinitis Pigmentosa (RP), lead to a retina …
Characteristics of the nerve barrier and the blood dorsal root ganglion barrier in health and disease
AK Reinhold, HL Rittner - Experimental neurology, 2020 - Elsevier
A variety of barriers ensures the protection of the peripheral nervous system from noxious
blood-borne or surrounding stimuli. In this review, anatomy and functioning of the blood …
blood-borne or surrounding stimuli. In this review, anatomy and functioning of the blood …
Claudins in renal physiology and pathology
C Prot-Bertoye, P Houillier - Genes, 2020 - mdpi.com
Claudins are integral proteins expressed at the tight junctions of epithelial and endothelial
cells. In the mammalian kidney, every tubular segment express a specific set of claudins that …
cells. In the mammalian kidney, every tubular segment express a specific set of claudins that …
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis
M Vall-Palomar, L Madariaga, G Ariceta - Pediatric Nephrology, 2021 - Springer
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC; OMIM
248250) is a rare autosomal recessive kidney disease caused by mutations in the CLDN16 …
248250) is a rare autosomal recessive kidney disease caused by mutations in the CLDN16 …
Inducible pluripotent stem cells to model and treat inherited degenerative diseases of the outer retina: 3D-organoids limitations and bioengineering solutions
M Andreazzoli, I Barravecchia, C De Cesari… - Cells, 2021 - mdpi.com
Inherited retinal degenerations (IRD) affecting either photoreceptors or pigment epithelial
cells cause progressive visual loss and severe disability, up to complete blindness. Retinal …
cells cause progressive visual loss and severe disability, up to complete blindness. Retinal …
Knockdown of claudin-19 in the retinal pigment epithelium is accompanied by slowed phagocytosis and increased expression of SQSTM1
F Liu, S Peng, RA Adelman… - … ophthalmology & visual …, 2021 - iovs.arvojournals.org
Purpose: Besides regulating paracellular diffusion, claudin-19 modulates the expression of
proteins essential for the retinal pigment epithelium (RPE). This study asks how RPE …
proteins essential for the retinal pigment epithelium (RPE). This study asks how RPE …
Claudins regulate gene and protein expression of the retinal pigment epithelium independent of their association with tight junctions
F Liu, T Xu, S Peng, RA Adelman, LJ Rizzolo - Experimental Eye Research, 2020 - Elsevier
Claudin-19 is the major claudin in the tight junctions of the retinal pigment epithelium (RPE).
Claudin-3 is also uniformly expressed albeit in lesser amounts. Besides modulating …
Claudin-3 is also uniformly expressed albeit in lesser amounts. Besides modulating …