Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high
mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and …

The endothelium layer lining the inner surface of blood vessels serves relevant
physiological functions in all body systems, including the exchanges between blood and …

Cerebral malaria (CM) is a life-threatening form of Plasmodium falciparum infection caused
by brain inflammation. Brain endothelium dysfunction is a hallmark of CM pathology, which …

Type I interferons (IFN-Is) are important cytokines playing critical roles in various infections,
autoimmune diseases, and cancer. Studies have also shown that IFN-Is exhibit …

Despite significant progress in combating malaria in recent years the burden of severe
disease and death due to Plasmodium infections remains a global public health concern …

Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …

Type I interferons (IFNs) are a family of cytokines with a wide range of biological activities
including anti‐viral and immune‐regulatory functions. Here, we focus on the protozoan …

Malaria comprises a spectrum of disease syndromes and the immune system is a major
participant in malarial disease. This is particularly true in relation to the immune responses …

Introduction Cerebral malaria (CM) lethality is attributable to induction of brain edema
induction but the cellular mechanisms involving brain microvascular endothelium in CM …

Recent initiatives to improve translation of findings from animal models to human disease
have focussed on reproducibility but quantifying the relevance of animal models remains a …