Quantifying the microstructural and macrostructural geometrical features of the human
brain's connections is necessary for understanding normal aging and disease. Here, we …

There is increasing interest in factors that may modulate white matter (WM) breakdown and,
consequentially, age-related cognitive and behavioral deficits. Recent diffusion tensor …

The structure and integrity of the ageing brain is interchangeably linked to physical health,
and cardiometabolic risk factors (CMRs) are associated with dementia and other brain …

Obesity is a preventable risk factor for cerebrovascular disorders and it is associated with
cerebral grey and white matter changes. Specifically, individuals with obesity show …

Importance Older adults with lower intake and tissue levels of long-chain ω-3
polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20: 5) and …

Little is known about a longitudinal decline in white matter microstructure and its
associations with cognition in preclinical dementia. Longitudinal diffusion tensor imaging …

While previous studies suggest the implication of herpes simplex virus (HSV) in the onset of
Alzheimer's disease (AD), no study has investigated its association with early neuroimaging …

Background The comorbidity between diabetes mellitus and depression was revealed, and
diabetes mellitus increased the prevalence of depressive disorder, which ranked 13th in the …

Abstract Apolipoprotein E ε4 (APOE4) is a strong genetic risk factor of Alzheimer's disease
and metabolic dysfunction. However, whether APOE4 and markers of metabolic dysfunction …

It is estimated that short association fibers running immediately beneath the cortex may
make up as much as 60% of the total white matter volume. However, these have been …