New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
K Ochi, T Hosaka - Applied microbiology and biotechnology, 2013 - Springer
Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each
strain contains genes that encode the enzymes to synthesize a plethora of potential …
strain contains genes that encode the enzymes to synthesize a plethora of potential …
The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining
H Xia, X Li, Z Li, X Zhan, X Mao, Y Li - Frontiers in microbiology, 2020 - frontiersin.org
Streptomyces is taken as an important resource for producing the most abundant antibiotics
and other bio-active natural products, which have been widely used in pharmaceutical and …
and other bio-active natural products, which have been widely used in pharmaceutical and …
Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects
K Ochi - The Journal of antibiotics, 2017 - nature.com
As bacteria and fungi have been found to contain genes encoding enzymes that synthesize
a plethora of potential secondary metabolites, interest has grown in the activation of these …
a plethora of potential secondary metabolites, interest has grown in the activation of these …
Biotechnological and industrial applications of Streptomyces metabolites
Streptomyces sp. produces clinically important bioactive compounds with anticancer,
antiviral, and antibacterial properties. These compounds have important roles in various …
antiviral, and antibacterial properties. These compounds have important roles in various …
Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes
Y Tanaka, M Komatsu, S Okamoto… - Applied and …, 2009 - Am Soc Microbiol
Certain streptomycin resistance mutations (ie, rpsL and rsmG) result in the overproduction of
antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a …
antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a …
A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene
R Dai, J He, X Zha, Y Wang, X Zhang… - PLoS neglected …, 2021 - journals.plos.org
Streptomycin is considered to be one of the effective antibiotics for the treatment of plague.
In order to investigate the streptomycin resistance of Y. pestis in China, we evaluated …
In order to investigate the streptomycin resistance of Y. pestis in China, we evaluated …
Production of xylanase by an alkaline-tolerant marine-derived Streptomyces viridochromogenes strain and improvement by ribosome engineering
Z Liu, X Zhao, F Bai - Applied Microbiology and Biotechnology, 2013 - Springer
Xylanase is the enzyme complex that is responsible for the degradation of xylan; however,
novel xylanase producers remain to be explored in marine environment. In this study, a …
novel xylanase producers remain to be explored in marine environment. In this study, a …
Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination …
N Benslimane, C Loret, P Chazelas, F Favreau… - Pharmaceuticals, 2024 - mdpi.com
Nonsense mutations that generate a premature termination codon (PTC) can induce both
the accelerated degradation of mutated mRNA compared with the wild type version of the …
the accelerated degradation of mutated mRNA compared with the wild type version of the …
Properties of Streptomyces albus J1074 mutant deficient in tRNALeu UAA gene bldA
Streptomyces albus J1074 is one of the most popular and convenient hosts for heterologous
expression of gene clusters directing the biosynthesis of various natural metabolic products …
expression of gene clusters directing the biosynthesis of various natural metabolic products …
Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor
A Yepes, S Rico, A Rodríguez-García, RI Santamaría… - PLoS …, 2011 - journals.plos.org
The abundance of two-component systems (TCSs) in Streptomyces coelicolor A3 (2)
genome indicates their importance in the physiology of this soil bacteria. Currently, several …
genome indicates their importance in the physiology of this soil bacteria. Currently, several …