New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

K Ochi, T Hosaka - Applied microbiology and biotechnology, 2013 - Springer
Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each
strain contains genes that encode the enzymes to synthesize a plethora of potential …

The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining

H Xia, X Li, Z Li, X Zhan, X Mao, Y Li - Frontiers in microbiology, 2020 - frontiersin.org
Streptomyces is taken as an important resource for producing the most abundant antibiotics
and other bio-active natural products, which have been widely used in pharmaceutical and …

Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects

K Ochi - The Journal of antibiotics, 2017 - nature.com
As bacteria and fungi have been found to contain genes encoding enzymes that synthesize
a plethora of potential secondary metabolites, interest has grown in the activation of these …

Biotechnological and industrial applications of Streptomyces metabolites

Khushboo, P Kumar, KK Dubey… - Biofuels, Bioproducts …, 2022 - Wiley Online Library
Streptomyces sp. produces clinically important bioactive compounds with anticancer,
antiviral, and antibacterial properties. These compounds have important roles in various …

Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes

Y Tanaka, M Komatsu, S Okamoto… - Applied and …, 2009 - Am Soc Microbiol
Certain streptomycin resistance mutations (ie, rpsL and rsmG) result in the overproduction of
antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a …

A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene

R Dai, J He, X Zha, Y Wang, X Zhang… - PLoS neglected …, 2021 - journals.plos.org
Streptomycin is considered to be one of the effective antibiotics for the treatment of plague.
In order to investigate the streptomycin resistance of Y. pestis in China, we evaluated …

Production of xylanase by an alkaline-tolerant marine-derived Streptomyces viridochromogenes strain and improvement by ribosome engineering

Z Liu, X Zhao, F Bai - Applied Microbiology and Biotechnology, 2013 - Springer
Xylanase is the enzyme complex that is responsible for the degradation of xylan; however,
novel xylanase producers remain to be explored in marine environment. In this study, a …

Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination …

N Benslimane, C Loret, P Chazelas, F Favreau… - Pharmaceuticals, 2024 - mdpi.com
Nonsense mutations that generate a premature termination codon (PTC) can induce both
the accelerated degradation of mutated mRNA compared with the wild type version of the …

Properties of Streptomyces albus J1074 mutant deficient in tRNALeu UAA gene bldA

O Koshla, M Lopatniuk, I Rokytskyy, O Yushchuk… - Archives of …, 2017 - Springer
Streptomyces albus J1074 is one of the most popular and convenient hosts for heterologous
expression of gene clusters directing the biosynthesis of various natural metabolic products …

Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor

A Yepes, S Rico, A Rodríguez-García, RI Santamaría… - PLoS …, 2011 - journals.plos.org
The abundance of two-component systems (TCSs) in Streptomyces coelicolor A3 (2)
genome indicates their importance in the physiology of this soil bacteria. Currently, several …