Chronic pain patients often develop mental disorders, and anxiety disorders are common.
We hypothesize that the comorbid anxiety results from an imbalance between the reward …

We demonstrate that the rate of extracellular signal-related kinase phosphorylation (P-
ERK1, 2/Total-ERK1, 2) in the amygdala is negatively and independently associated with …

This report evaluates the effects of chlordiazepoxide, a benzodiazepine commonly
prescribed to manage anxiety-related disorders in adolescent/pediatric populations, on …

Chronic neuropathic pain caused by nerve damage is a most common clinical symptom,
often accompanied by anxiety-and depression-like symptoms. Current treatments are very …

Ketamine is an ionic glutamic acid N-methyl-d-aspartate receptor (NMDAR) antagonist
commonly used in clinical anesthesia, and its rapid and lasting antidepressant effect has …

Calcitonin gene-related peptide (CGRP) is a neuropeptide that causes anxiety behavior;
however, the underlying mechanisms remain unclear. We found that CGRP modulates …

The objective of this study was to evaluate whether juvenile fluoxetine (FLX) exposure
induces long-term changes in baseline responses to anxiety-inducing environments, and if …

Prior studies suggest that individual differences in stress responses contribute to the
pathogenesis of neuropsychiatric disorders. In the present study, we investigated the role of …

Background: Fluoxetine (FLX) represents the antidepressant of choice for the management
of pediatric mood-related illnesses. Accumulating preclinical evidence suggests that …

Anxiety-related illnesses constitute one of the leading causes of disability across the globe.
Consequently, the need for validated preclinical models to uncover the etiology of anxiety …