Current status of pan-genome analysis for pathogenic bacteria
Highlights•Wealth of genome data are making pan-genome analysis increasingly
possible.•Pan-genome analysis is an effective approach to understand pathogenic …
possible.•Pan-genome analysis is an effective approach to understand pathogenic …
[HTML][HTML] International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact
Background Pneumococcal conjugate vaccines have reduced the incidence of invasive
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
Diversification of colonization factors in a multidrug-resistant Escherichia coli lineage evolving under negative frequency-dependent selection
Escherichia coli is a major cause of bloodstream and urinary tract infections globally. The
wide dissemination of multidrug-resistant (MDR) strains of extraintestinal pathogenic E. coli …
wide dissemination of multidrug-resistant (MDR) strains of extraintestinal pathogenic E. coli …
[HTML][HTML] Puzzling over the pneumococcal pangenome
The Gram positive bacterium Streptococcus pneumoniae (pneumococcus) is a major human
pathogen. It is a common colonizer of the human host, and in the nasopharynx, sinus, and …
pathogen. It is a common colonizer of the human host, and in the nasopharynx, sinus, and …
[HTML][HTML] Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci
T Azarian, PK Mitchell, M Georgieva… - PLoS …, 2018 - journals.plos.org
Streptococcus pneumoniae serotype 3 remains a significant cause of morbidity and mortality
worldwide, despite inclusion in the 13-valent pneumococcal conjugate vaccine (PCV13) …
worldwide, despite inclusion in the 13-valent pneumococcal conjugate vaccine (PCV13) …
Pneumococcal serotype trends, surveillance and risk factors in UK adult pneumonia, 2013–18
H Pick, P Daniel, C Rodrigo, T Bewick, D Ashton… - Thorax, 2020 - thorax.bmj.com
Background Changes over the last 5 years (2013–18) in the serotypes implicated in adult
pneumococcal pneumonia and the patient groups associated with vaccine-type disease are …
pneumococcal pneumonia and the patient groups associated with vaccine-type disease are …
[HTML][HTML] Bacterial factors required for transmission of Streptococcus pneumoniae in mammalian hosts
The capacity of Streptococcus pneumoniae to successfully transmit and colonize new
human hosts is a critical aspect of pneumococcal population biology and a prerequisite for …
human hosts is a critical aspect of pneumococcal population biology and a prerequisite for …
[HTML][HTML] Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae
Predicting how pathogen populations will change over time is challenging. Such has been
the case with Streptococcus pneumoniae, an important human pathogen, and the …
the case with Streptococcus pneumoniae, an important human pathogen, and the …
Prediction of post-PCV13 pneumococcal evolution using invasive disease data enhanced by inverse-invasiveness weighting
X Qiu, L McGee, LL Hammitt, LR Grant, KL O'Brien… - mBio, 2024 - journals.asm.org
After introducing pneumococcal conjugate vaccines (PCVs), serotype replacement occurred
in Streptococcus pneumoniae. Predicting which pneumococcal strains will become common …
in Streptococcus pneumoniae. Predicting which pneumococcal strains will become common …
Pneumococcal quorum sensing drives an asymmetric owner–intruder competitive strategy during carriage via the competence regulon
Competition among microorganisms is a key determinant of successful host colonization
and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing …
and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing …