Diabetes mellitus (DM) is a major metabolic disorder due to hyperglycemia, which is
increasing all over the world. From the last two decades, the use of synthetic agents has …

In the present work we report the experimental and computational investigations of (2-
aminophenyl)[4-(4-chlorophenyl)-1, 3-diphenyl-1H-pyrazol-5-yl] methanone (C 28 H 20 ClN …

The diseases-related complications and causes are threaded. Accordingly, the preparation
of one drug with multiple targets is very pressing. In this context, the three series of pyrazole …

Diabetes is a chronic metabolic disorder that impacts all age groups and affects a large
population worldwide. Humans receive glucose from almost every food source, and after …

Six half-sandwich Ru (II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2, 4-
dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and …

Synthesis of a new series of spiropyrazole derivatives using microwaves irradiation with
high yield in minutes was achieved through a cycloaddition reaction of nitrile imines and …

The compounds, 1H-Isochromene and pyran carbonitrile were synthesized from the
pyrazole aldehyde derivatives through efficient synthetic routes and characterization was …

This article describes studies on the design, synthesis, and biological evaluation of pyrazole‐
containing β‐amino carbonyl compounds (5a–5q) as DPP‐4 inhibitors and anti‐diabetic …

The main building blocks for the production of flavonoids and iso-flavonoids are chalcones.
Chalcones are α, β-unsaturated carbonyl compounds containing three carbons. The …

Background: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of
disease, with an estimated global cost of> 800 billion USD annually. For this reason, the …