Background Widely used for acute pain management, the clinical benefit from perioperative
use of gabapentinoids is uncertain. The aim of this systematic review was to assess the …

The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

The focus of perioperative pain management should be to attempt to minimise the
nociceptive input and reduce the risk of transition to central sensitisation. Gabapentinoids …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

Background Gabapentin is a recommended first‐line agent for treating neuropathic pain;
however, its efficacy rate is reportedly low, and the risk of adverse events is high. A plausible …

Antiepileptic drugs (AEDs) are extensively used worldwide to treat a wide range of disorders
other than epilepsy, such as neuropathic pain, migraine, and bipolar disorder. Due to this …

The gabapentinoid drugs, gabapentin and pregabalin, are first-line treatments for
neuropathic pain. The epidemics of chronic pain and opioid misuse have given rise to the …

Over 230 million people worldwide undergo surgery each year, with this number increasing
annually [1]. More than 80% of surgical patients experience acute postoperative pain …

Chronic pain, often defined as any pain lasting more than 3 months, is poorly managed
because of its multifaceted and complex mechanisms. Calcium/calmodulin-dependent …