[HTML][HTML] Osteoporosis: Pathophysiology and therapeutic options

U Föger-Samwald, P Dovjak, U Azizi-Semrad… - EXCLI …, 2020 - ncbi.nlm.nih.gov
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic
bone resorption not compensated by osteoblastic bone formation. This causes bones to …

The gut microbiome and sex hormone-related diseases

S He, H Li, Z Yu, F Zhang, S Liang, H Liu… - Frontiers in …, 2021 - frontiersin.org
The role of the gut microbiome has been a hot topic in recent years. One aim of this review is
to shed light on the crosstalk between sex hormones and the gut microbiome. Researchers …

Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure

M Guo, H Liu, Y Yu, X Zhu, H Xie, C Wei, C Mei… - Gut …, 2023 - Taylor & Francis
Background With increasing knowledge about the gut–bone axis, more studies for
treatments based on the regulation of postmenopausal osteoporosis by gut microbes are …

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Z Lyu, Y Hu, Y Guo, D Liu - Bone research, 2023 - nature.com
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …

Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis

W Zhang, R Gao, X Rong, S Zhu, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …

Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone

R Gruber - Journal of Clinical Periodontology, 2019 - Wiley Online Library
Aim Osteoimmunology covers the cellular and molecular mechanisms responsible for
inflammatory osteolysis that culminates in the degradation of alveolar bone …

The microbiota-gut-bone axis and bone health

Y Tu, R Yang, X Xu, X Zhou - Journal of leukocyte biology, 2021 - academic.oup.com
The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria,
fungi, and viruses, known as the “second gene pool” of the human body. In recent years, the …

The role of gut microbiota in bone homeostasis

J Behera, J Ison, SC Tyagi, N Tyagi - Bone, 2020 - Elsevier
The gut microbiota (GM) is referred to as the second gene pool of the human body and a
commensal, symbiotic, and pathogenic microorganism living in our intestines. The …

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice

L Sapra, HY Dar, A Bhardwaj, A Pandey, S Kumari… - Scientific reports, 2021 - nature.com
Osteoporosis is a systemic-skeletal disorder characterized by enhanced fragility of bones
leading to increased rates of fractures and morbidity in large number of populations …

Crosstalk between the gut microbiota and postmenopausal osteoporosis: Mechanisms and applications

Q Xu, D Li, J Chen, J Yang, J Yan, Y Xia… - International …, 2022 - Elsevier
Postmenopausal osteoporosis (PMO) results from a reduction in bone mass and
microarchitectural deterioration in bone tissue due to estrogen deficiency, which may …