The lung parenchyma comprises a large number of thin-walled alveoli, forming an
enormous surface area, which serves to maintain proper gas exchange. The alveoli are held …

The mechanical impedance of the respiratory system defines the pressure profile required to
drive a unit of oscillatory flow into the lungs. Impedance is a function of oscillation frequency …

We discuss herein the theory as well as some design considerations of magnetic tweezers.
This method of generating force on magnetic particles bound to biological entities is shown …

Asthma is an obstructive airway disease, with a heterogeneous and multifactorial
pathogenesis. Although generally considered to be a disease principally driven by chronic …

Airway hyper-responsiveness associated with asthma is mediated by airway smooth muscle
cells (SMCs) and has a complicated etiology involving increases in cell contraction and …

In this paper, we develop a total lung model based on a tree of 0D airway and acinar models
for studying respiratory mechanics during spontaneous breathing. This model utilizes both …

This study was undertaken to determine whether a smaller lung volume or a stiffer lung
tissue accounts for the greater lung elastance of C57BL/6 than BALB/c mice. The …

Microtubules are structural components of the cytoskeleton that determine cell shape,
polarity, and motility in cooperation with the actin filaments. In order to determine the role of …

Studies on isolated tracheal airway smooth muscle (ASM) strips have shown that
length/force fluctuations, similar to those likely occurring during breathing, will mitigate ASM …

BACKGROUND: Human trachea is a multi-component structure composed of cartilage,
trachealis muscle, mucosa and submucosa membrane and adventitial membrane. Its …