The use of organophosphorus pesticides results in toxicity risk to non-target organisms.
Organophosphorus compounds share a common mode of action, exerting their toxic effects …

During more than five decades, pyridinium oximes have been developed as therapeutic
agents used in the medical treatment of poisoning with organophosphorus compounds …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with multifactorial
causes that requires multitargeted treatment. Inhibitors of acetylcholinesterase (AChE) and …

Organophosphate pesticides (OPPs; eg chlorpyrifos, diazinon, paraoxon) are a wide and
heterogeneous group of organophosphorus compounds. Their biological activity of …

Background Based on in vitro and in vivo rat experiments, the newly developed
acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the …

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate
intoxication. Among the organophosphates, with the exception of soman, tabun (GA) …

The availability of highly toxic organophosphorus (OP) warfare agents (nerve agents)
underlines the necessity for an effective medical treatment. Acute OP toxicity is primarily …

Biosensors are available and applicable for detection and characterization of specific
inhibitors of many enzymes. In this review, biosensors based on fixed acetylcholinesterase …

Inappropriate use of toxic chemicals is common in developing countries, where it leads to
excessive exposure and high risks of unintentional poisoning. Risks are particularly high …

The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in
ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) …