Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …

Abstract Background Hydrogen peroxide (H 2 O 2)-induced mitochondrial oxidative damage
is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H 2 O 2 …

Background: Allicin, a major component of garlic, is regarded as a cardioprotective agent
and is associated with increased endothelial function. Methods: The effects of allicin on …

Oxidative stress is a vital contributor to the development and progression of diabetes-
accelerated atherosclerosis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known …

Atherosclerosis is closely associated with the inflammatory reaction of vascular endothelial
cells. Puerarin (Pue), the main active component isolated from the rhizome of Pueraria …

Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality due to
chronic arterial injury caused by hyperlipidemia, hypertension, inflammation and oxidative …

Background Potential routes whereby systemic inflammation, oxidative stress and
mitochondrial dysfunction may drive the development of endothelial dysfunction and …

Catalpol, an iridoid glucoside, has been found present in large quantities in the root of
Rehmannia glutinosa L. and showed a strong antioxidant capacity in the previous study. In …

In the first part of this review, we summarize basic mitochondrial bioenergetics concepts
showing that mitochondria are critical regulators of cell life and death. Until a few decades …