ABCB1 and ABCG2 regulation at the blood-brain barrier: potential new targets to improve brain drug delivery
The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …
Role of microenvironment in glioma invasion: what we learned from in vitro models
I Manini, F Caponnetto, A Bartolini, T Ius… - International journal of …, 2018 - mdpi.com
The invasion properties of glioblastoma hamper a radical surgery and are responsible for its
recurrence. Understanding the invasion mechanisms is thus critical to devise new …
recurrence. Understanding the invasion mechanisms is thus critical to devise new …
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
Tumour-associated macrophages (TAMs) are enriched in glioblastoma multiformes (GBMs)
that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation …
that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation …
Symbiotic macrophage-glioma cell interactions reveal synthetic lethality in PTEN-null glioma
Heterotypic interactions across diverse cell types can enable tumor progression and hold
the potential to expand therapeutic interventions. Here, combined profiling and functional …
the potential to expand therapeutic interventions. Here, combined profiling and functional …
[HTML][HTML] Reciprocal signaling between glioblastoma stem cells and differentiated tumor cells promotes malignant progression
Glioblastoma is the most lethal primary brain tumor; however, the crosstalk between
glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we …
glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we …
β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages
Glioblastoma (GBM) is a complex ecosystem that includes a heterogeneous tumor
population and the tumor-immune microenvironment (TIME), prominently containing tumor …
population and the tumor-immune microenvironment (TIME), prominently containing tumor …
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays
crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain …
crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain …
Systemic T cells immunosuppression of glioma stem cell-derived exosomes is mediated by monocytic myeloid-derived suppressor cells
R Domenis, D Cesselli, B Toffoletto, E Bourkoula… - PLoS …, 2017 - journals.plos.org
A major contributing factor to glioma development and progression is its ability to evade the
immune system. Nano-meter sized vesicles, exosomes, secreted by glioma-stem cells …
immune system. Nano-meter sized vesicles, exosomes, secreted by glioma-stem cells …
Bioinformatic profiling identifies an immune-related risk signature for glioblastoma
Objective: To investigate the local immune status and its prognostic value in glioma.
Methods: A cohort of 297 glioma samples with whole genome microarray expression data …
Methods: A cohort of 297 glioma samples with whole genome microarray expression data …
Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice
L Zhang, D Alizadeh, M Van Handel, M Kortylewski… - Glia, 2009 - Wiley Online Library
As the main effector‐cell population of the central nervous system, microglia (MG) are
considered to play an important immunoregulatory function in a number of pathological …
considered to play an important immunoregulatory function in a number of pathological …