Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …

PML nuclear bodies are matrix-associated domains that recruit an astonishing variety of
seemingly unrelated proteins. Since their discovery in the early 1960s, PML bodies have …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

Promyelocytic leukemia nuclear bodies (PML-NBs) are PML-based nuclear structures that
regulate various cellular processes. SUMOylation, the process of covalently conjugating …

Members of the tripartite motif (TRIM) protein family are involved in various cellular
processes, including cell proliferation, differentiation, development, oncogenesis and …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

Nuclear domain 10 (ND10), also referred to as nuclear bodies, are discrete
interchromosomal accumulations of several proteins including promyelocytic leukemia …

Spinal muscular atrophy (SMA) is a common, often fatal, autosomal recessive disease
leading to progressive muscle wasting and paralysis as a result of degeneration of anterior …

In senescent cells, specialized domains of transcriptionally silent senescence-associated
heterochromatic foci (SAHF), containing heterochromatin proteins such as HP1, are thought …