The chemokine CXCL12 (SDF-1) and its cell surface receptor CXCR4 were first identified as
regulators of lymphocyte trafficking to the bone marrow. Soon after, the CXCL12/CXCR4 …

Neutrophils are phagocytes whose principal function is to maintain anti-bacterial immunity.
Neutrophils ingest and kill invading bacteria, releasing cytotoxic, chemotactic and …

In the bone marrow, hematopoietic stem cells (HSCs) reside in specific niches near
osteoblast-lineage cells at the endosteum. To investigate the regulation of these endosteal …

The host tissue microenvironment influences malignant cell proliferation and metastasis, but
little is known about how tumor-induced changes in the microenvironment affect benign …

Breast cancer metastatic relapse can occur years after therapy, indicating that disseminated
breast cancer cells (BCCs) have a prolonged dormant phase before becoming proliferative …

Abstract The CXCR4–SDF-1 axis plays a central role in the trafficking and retention of
normal and malignant stem cells in the bone marrow (BM) microenvironment. Here, we used …

Fucoidan is a fucose-containing sulfated polysaccharide derived from brown seaweeds,
crude extracts of which are commercially available as nutritional supplements. Recent …

Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

Accumulating laboratory studies have implicated the mobilization of bone marrow (BM)-
derived stem cells in brain plasticity and stroke therapy. This mobilization of bone cells to the …

Ischemic cardiomyopathy is one of the main causes of death, which may be prevented by
stem cell-based therapies. SDF-1α is the major chemokine attracting stem cells to the heart …