Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

Oxidative stress is defined as an imbalance between production of free radicals and reactive
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …

Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Cancer is one of the major causes of death in the world and its global burden is expected to
continue increasing. In several types of cancers, reactive oxygen species (ROS) have been …

Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and
signaling. Various oncogenic pathways such as proliferation and evading cell death …

Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC),
but its clinical effects are still limited. In this study we identify Quiescin sulfhydryl oxidase 1 …