The basic premise of the epitope-based approach to vaccine development is that, in certain
cases, the responses induced by the natural immunogen are not optimal, and can be …

Background Class I major histocompatibility complex (MHC) molecules bind, and present to
T cells, short peptides derived from intracellular processing of proteins. The peptide …

The highly polymorphic human leukocyte antigen (HLA) class I molecules help to determine
the specificity and repertoire of the immune response. The great diversity of these antigen …

Suspicion that host genetic factors determine variability in the course of natural HIV-1
infection deepened throughout the 1980s and early 1990s [1, 2], but only relatively recently …

Objective: To determine the correlation between polymorphisms in the IL-4 gene cluster and
resistance to HIV-1 infection. Design: A cross-sectional genetic analysis of polymorphisms …

Objective We examined the association between mother-to-child human T cell lymphotropic
virus type I (HTLV-I) transmission and human leukocyte antigen (HLA) class I types Methods …

Objective: A group of commercial sex workers in the Pumwani Sex Worker Cohort,
established in 1985 in Nairobi, Kenya, remain HIV-1 uninfected despite heavy exposure to …

With the rise in novel infectious agents and disease pandemics, a new era of vaccine
discovery is necessary. To address this, the new field of immunomics is described, which is …

Background During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively
stable quantitative trait that has clinical and epidemiological implications. Immunogenetic …

The major histocompatibility complex (MHC) harbours genes whose primary function in
regulating immune responsiveness to infection is to present foreign antigens to cytotoxic T …