Increased serum uric acid (SUA) levels are commonly seen in patients with metabolic
syndrome and are widely accepted as risk factors for hypertension, gout, non-alcoholic fatty …

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose
tissue dysfunction and contributing to obesity-induced inflammation and metabolic …

Insulin resistance is the major pathological characteristic of type 2 diabetes, and the elderly
often develop insulin resistance. However, the deep-seated mechanisms for aging-related …

Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress,
promoting the progression of metabolic disease such as diabetes, hyperlipidemia …

A primary obstacle in translating genetic associations with disease into therapeutic
strategies is elucidating the cellular programs affected by genetic risk variants and effector …

Objective In gout, autoinflammatory responses to urate crystals promote acute arthritis flares,
but the pathogeneses of tophi, chronic synovitis, and erosion are less well understood …

SPARC-deficient mice have been shown to exhibit impaired glucose tolerance and insulin
secretion, but the underlying mechanism remains unknown. Here, we showed that SPARC …

Dengchuan cattle are the only dairy yellow cattle and endangered cattle among Yunnan
native cattle breeds. However, its genetic background remains unclear. Here, we performed …

Background Although studies have shown that waist circumference (WC) is positively
associated with an increased risk of cardiovascular diseases among the normal population …

CAR T cell therapies face challenges in combating solid tumors due to their single-target
approach, which becomes ineffective if the targeted antigen is absent or lost. Universal CAR …