The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

Inositols are sugar-like compounds that are widely distributed in nature and are a part of
membrane molecules, participating as second messengers in several cell-signaling …

Background: The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor
that awaits a formal classification. There are an increasing number of reports directed to …

Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

Lysophosphatidylinositols (LPIs) are membrane constituents that alter the properties of said
membranes. However, recent data showing that the once orphan receptor, GPR55, can act …

The accumulation of amyloid-β (Aβ) peptides in the brain is considered to be the initial event
in the Alzheimer's disease (AD). Neurotoxicity mediated by Aβ has been demonstrated to …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cascading
changes in cognition and behavior. G-protein-coupled receptor 55 (GPR55) has been used …

GPR55 is a G-protein-coupled receptor (GPCR) that has been identified as a new
cannabinoid receptor. Given the wide localization of GPR55 in brain and peripheral tissues …