Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

The A3 adenosine receptor (A3AR) subtype is a novel, promising therapeutic target for
inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver …

The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …

Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

The physiological role of the adenosine A 3 receptor is being investigated using newly
synthesized, selective ligands. Recently, in addition to agonists, selective antagonists have …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

Adenosine in a signaling nucleoside eliciting many physiological responses. Elevated levels
of adenosine have been found in bronchoalveolar lavage, blood and exhaled breath …

Adenosine administration by inhalation elicits concentration-related bronchoconstriction in
subjects with asthma and chronic obstructive pulmonary disease (COPD). The mechanisms …