Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
NF-κB signaling in macrophages: dynamics, crosstalk, and signal integration
MG Dorrington, IDC Fraser - Frontiers in immunology, 2019 - frontiersin.org
The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …
related pathways thanks to almost four decades of intense research. NF-κB signaling is …
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning
A principal challenge in the analysis of tissue imaging data is cell segmentation—the task of
identifying the precise boundary of every cell in an image. To address this problem we …
identifying the precise boundary of every cell in an image. To address this problem we …
Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Joint single-cell measurements of nuclear proteins and RNA in vivo
Identifying gene-regulatory targets of nuclear proteins in tissues is a challenge. Here we
describe intranuclear cellular indexing of transcriptomes and epitopes (inCITE-seq), a …
describe intranuclear cellular indexing of transcriptomes and epitopes (inCITE-seq), a …
Signaling via the NFκB system
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …
development, immune responses, inflammation, and cancer. The NFκB signaling system …
TNF biology, pathogenic mechanisms and emerging therapeutic strategies
GD Kalliolias, LB Ivashkiv - Nature reviews rheumatology, 2016 - nature.com
TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …
NF-κB and the transcriptional control of inflammation
JP Mitchell, RJ Carmody - International review of cell and molecular …, 2018 - Elsevier
The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …
master regulator of inflammation and immune homeostasis. It achieves this status by means …
Inhibitory feedback control of NF-κB signalling in health and disease
JA Prescott, JP Mitchell, SJ Cook - Biochemical Journal, 2021 - portlandpress.com
Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
The regulation of NF-κB subunits by phosphorylation
F Christian, EL Smith, RJ Carmody - Cells, 2016 - mdpi.com
The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …