IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …

Ruthenium complexes are a new generation of metal antitumor drugs that are currently of
great interest in multidisciplinary research. In this review article, we introduce the …

Background Despite widespread acceptance that neuroinflammation contributes to age-
related cognitive decline, studies comparing protein expression of cytokines in the young …

Tumor cells adapt to diverse survival strategies defying our pursuit of multimodal cancer
therapy. Prostate cancer (PCa) is an example that is resistant to one of the most potent …

The tyrosine kinase activity of epidermal growth factor receptors (EGFRs) plays critical roles
in cell proliferation, regeneration, tumorigenesis, and anticancer resistance. Non-small-cell …

Abstract Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor
response to checkpoint inhibitors and is known to chemoattract and activate …

CXCL8 (also known as IL‐8) can produce different biological effects by binding to its
receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 …

CD73, a cell surface 5′ nucleotidase that generates adenosine, has emerged as an
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …

EGFR is a member of the ERBB family. It plays a significant role in cellular processes such
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …

Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with
chemotherapy in patients with RAS wild type metastatic colorectal cancer (mCRC) has …