Roles of IL-1 in cancer: from tumor progression to resistance to targeted therapies
V Gelfo, D Romaniello, M Mazzeschi, M Sgarzi… - International journal of …, 2020 - mdpi.com
IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …
inflammatory activity. Beyond its biological role as a regulator of the innate immune …
Applications of ruthenium complex in tumor diagnosis and therapy
K Lin, ZZ Zhao, HB Bo, XJ Hao, JQ Wang - Frontiers in Pharmacology, 2018 - frontiersin.org
Ruthenium complexes are a new generation of metal antitumor drugs that are currently of
great interest in multidisciplinary research. In this review article, we introduce the …
great interest in multidisciplinary research. In this review article, we introduce the …
Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions
L Porcher, S Bruckmeier, SD Burbano… - Journal of …, 2021 - Springer
Background Despite widespread acceptance that neuroinflammation contributes to age-
related cognitive decline, studies comparing protein expression of cytokines in the young …
related cognitive decline, studies comparing protein expression of cytokines in the young …
New pathway for cisplatin prodrug to utilize metabolic substrate preference to overcome cancer intrinsic resistance
Tumor cells adapt to diverse survival strategies defying our pursuit of multimodal cancer
therapy. Prostate cancer (PCa) is an example that is resistant to one of the most potent …
therapy. Prostate cancer (PCa) is an example that is resistant to one of the most potent …
Molecular and clinical features of EGFR-TKI-associated lung injury
T Ohmori, T Yamaoka, K Ando, S Kusumoto… - International Journal of …, 2021 - mdpi.com
The tyrosine kinase activity of epidermal growth factor receptors (EGFRs) plays critical roles
in cell proliferation, regeneration, tumorigenesis, and anticancer resistance. Non-small-cell …
in cell proliferation, regeneration, tumorigenesis, and anticancer resistance. Non-small-cell …
A therapeutically actionable protumoral axis of cytokines involving IL-8, TNFα, and IL-1β
I Olivera, R Sanz-Pamplona, E Bolaños, I Rodriguez… - Cancer discovery, 2022 - AACR
Abstract Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor
response to checkpoint inhibitors and is known to chemoattract and activate …
response to checkpoint inhibitors and is known to chemoattract and activate …
[Retracted] The Crucial Role of CXCL8 and Its Receptors in Colorectal Liver Metastasis
Y Bie, W Ge, Z Yang, X Cheng, Z Zhao, S Li… - Disease …, 2019 - Wiley Online Library
CXCL8 (also known as IL‐8) can produce different biological effects by binding to its
receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 …
receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 …
CD73's potential as an immunotherapy target in gastrointestinal cancers
JB Harvey, LH Phan, OE Villarreal… - Frontiers in …, 2020 - frontiersin.org
CD73, a cell surface 5′ nucleotidase that generates adenosine, has emerged as an
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …
The story of EGFR: from signaling pathways to a potent anticancer target
S Ramani, S Samant, SM Manohar - Future Medicinal Chemistry, 2022 - Taylor & Francis
EGFR is a member of the ERBB family. It plays a significant role in cellular processes such
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …
Immune resistance and EGFR antagonists in colorectal cancer
Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with
chemotherapy in patients with RAS wild type metastatic colorectal cancer (mCRC) has …
chemotherapy in patients with RAS wild type metastatic colorectal cancer (mCRC) has …