Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters
in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) …

T790M mutation is the most common mechanism for resistance to first-and second-
generation tyrosine kinase inhibitors (TKI) for epidermal growth factor receptor (EGFR) …

Objective Liquid biopsies are being rapidly used in adult cancers as new biomarkers of
disease. Circulating tumor DNA (ctDNA) levels have been reported to be proportional to …

Background New prognostic markers are needed to identify patients with Ewing sarcoma
(EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the …

Purpose: Antibodies against insulin-like growth factor (IGF) type 1 receptor have shown
meaningful but transient tumor responses in patients with rhabdomyosarcoma (RMS). The …

The advent of dose intensified interval compressed therapy has improved event-free survival
for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a …

Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for
monitoring disease status of patients with advanced cancers. In melanoma, ctDNA has been …

Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with
potential applications during all stages of patient care, from diagnosis to long-term follow-up …

Bone sarcomas, although rare, are associated with significant morbidity and mortality. The
most frequent primary bone cancers include osteosarcoma, chondrosarcoma and Ewing …