For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and
natural history have been attempted. Despite the extensive amount of research regarding …

Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

Importance Synovitis is common and is associated with progression of structural
characteristics of knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage …

Osteoarthritis (OA) is the most common joint disease in the world, with an age-associated
increase in both incidence and prevalence. Clinical and epidemiologic research is crucial to …

Importance Sprifermin is under investigation as a disease-modifying osteoarthritis drug.
Objective To evaluate the effects of sprifermin on changes in total femorotibial joint cartilage …

Importance Even though osteoarthritis is a chronic and progressive disease,
pharmacological agents are mainly studied over short-term periods, resulting in unclear …

Introduction Regarding the efficacy of intra-articular injections of platelet-rich plasma,
hyaluronic acid and corticosteroids, current evidence is controversial. The superiority of one …

Objective The impact of increasing utilization of total knee arthroplasty (TKA) on lifetime
costs in persons with knee osteoarthritis (OA) is understudied. Methods We used the …

Background There is no cure for knee osteoarthritis (KOA) and typically patients live
approximately 30-years with the disease. Most common medical treatments result in short …

Knee osteoarthritis (KOA) is a common chronic debilitating disease with an estimated
prevalence of 23.9% in the general adult population. The condition is characterised by joint …