Most organisms (including humans) developed daily rhythms in almost every aspect of their
body. It is not surprising that rhythms are also related to affect in health and disease. In the …

The intensity of pain sensation exhibits marked day and night variations. Since the intensity
of pain perception is low during dark hours of the night when melatonin levels are high, this …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

Isolating exposed individuals from the unexposed ones is a crucial measure in breaking up
a chain of infection. All forms of separation and isolation, however, tend to impose an …

Introduction The prevalence of psychological disorders remains stable despite steady
increases in pharmacological treatments suggesting the need for auxiliary treatment options …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as a survival factor
for neurons. Agomelatine is a novel antidepressant as well as a potent agonist of melatonin …

Irritable bowel syndrome (IBS) is a common disorder characterized by recurrent abdominal
pain or discomfort, in combination with disturbed bowel habits in the absence of identifiable …

Introduction: Nowadays, the first-line medications in depression include SSRIs, SNRIs,
NDRIs, NaSSAs, SMSs, or a melatonin (M1/M2) receptor agonist and a 5-HT2C receptor …

Introduction: Agomelatine is an antidepressant with unique pharmacological actions; it is
both a melatonin agonist and selective serotonin antagonist. Both actions combined are …

Introduction: Disturbances of circadian rhythms and sleep play an important role in various
types of mood disorders like major depressive disorder (MDD), bipolar depressive disorder …