Emerging roles of NPQ/spexin in physiology and pathology

SY Lv, YC Zhou, XM Zhang, WD Chen… - Frontiers in …, 2019 - frontiersin.org
Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide.
Spexin gene and protein are widely expressed in central nervous system and peripheral …

Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease

S Kumar, RT Mankowski, SD Anton… - International Journal of …, 2021 - nature.com
Abstract Spexin (SPX) is a 14-amino acid neuropeptide, discovered recently using
bioinformatic techniques. It is encoded by the Ch12: orf39 gene that is widely expressed in …

[HTML][HTML] 30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and …

PA Kolodziejski, N Leciejewska, A Chmurzynska… - Molecular and Cellular …, 2021 - Elsevier
Spexin (SPX) is a 14 aa peptide discovered in 2007 using bioinformatics methods. SPX
inhibits food intake and regulates lipid, and carbohydrate metabolism. Here, we evaluate the …

Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors

M Behrooz, E Vaghef-Mehrabany… - Nutrition, Metabolism and …, 2020 - Elsevier
Background and aims Spexin (SPX) is a novel peptide recently discovered as an important
regulatory adipokine in obesity and related metabolic diseases. The aim of the current study …

Spexin levels are associated with metabolic syndrome components

NM Al-Daghri, A Alenad, H Al-Hazmi, OE Amer… - Disease …, 2018 - Wiley Online Library
Background. Spexin (SPX) is a novel peptide that is implicated in obesity and related energy
homeostasis in animals and adult humans. Little is known about its role in adults' overall …

Spexin: Its role, regulation, and therapeutic potential in the hypothalamus

A Tran, W He, JTC Chen, DD Belsham - Pharmacology & therapeutics, 2022 - Elsevier
Spexin is the most recently discovered member of the galanin/kisspeptin/spexin family of
peptides. This 14-amino acid peptide is highly conserved and is implicated in homeostatic …

Childhood obesity and adverse cardiometabolic risk in large for gestational age infants and potential early preventive strategies: a narrative review

S Viswanathan, K McNelis, K Makker, D Calhoun… - Pediatric …, 2022 - nature.com
Accumulating evidence indicates that obesity and cardiometabolic risks become established
early in life due to developmental programming and infants born as large for gestational age …

Evolution of structural and functional diversity of spexin in mammalian and non-mammalian vertebrate species

CH Lim, MYM Lee, T Soga, I Parhar - Frontiers in Endocrinology, 2019 - frontiersin.org
Spexin (SPX) is a novel neuropeptide, which was first identified in the human genome using
bioinformatics. Since then, orthologs of human SPX have been identified in mammalian and …

Emerging central and peripheral actions of spexin in feeding behavior, leptin resistance and obesity

M Yu, M Ju, P Fang, Z Zhang - Biochemical Pharmacology, 2022 - Elsevier
Consumption of a high calorie diet with irregular eating and sedentary behavior habits is
typical of the current suboptimal lifestyle, contributing to the development of metabolic …

Circulating spexin decreased and negatively correlated with systemic insulin sensitivity and pancreatic β cell function in obese children

T Chen, F Wang, Z Chu, L Sun, H Lv, W Zhou… - Annals of Nutrition and …, 2019 - karger.com
Objectives: Spexin (SPX) is a novel peptide that has recently emerged as an important
regulatory adipokine of obesity and related metabolic disease. Little is known about its role …