Importance of the field: Substance P is involved in mediating a number of biological effects
such as emesis, pain, inflammation, bronchoconstriction, antitumor activity, and regulation of …

Background Numerous molecules have been introduced to participate in the formation of
breast cancer, the most common malignancy in women. Among them, neuropeptide …

Chemotherapy-induced nausea and vomiting (CINV) continues to be one of the most
distressing side effects of chemotherapy in breast cancer patients, which can result in poor …

Breast cancer remains the most prevalent cancer among women in the United States.
Substance P, a peptide derived from the TAC1 gene, mediates oncogenic properties in …

Neurokinin-1 receptor (NK1R) occurs naturally on human glioblastomas. Its activation
mediates glioma cell proliferation. However, it is unknown whether NK1R is directly involved …

HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors
[194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT 3 class …

Substance P and its truncated receptor exert oncogenic effects. The high production of
substance P in breast cancer cells (BC Cs) is caused by the enhancement of tachykinin …

Breast cancer (BC) is a common reason of cancer-associated death in female. To develop
novel strategy of therapeutics, it is crucial to comprehensively understand the receptor status …

Cisplatin and related chemotherapeutics are potent emetogens in humans and least shrews,
a small animal emesis model which also vomits in response to substance P (SP). The SP …

This review discusses a family of receptors that interact with a family of small peptides that
belong to the tachykinin family. The three subtypes of tachykinin receptors follow the …