Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …

Senescence is a crucial player in several metabolic disorders and chronic inflammatory
diseases. Recent data prove the involvement of hepatocyte senescence in the development …

Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal
cells in the tumour microenvironment (TME), inducing a senescence-associated secretory …

Cell senescence is a fundamental mechanism of aging and appears to play vital roles in the
onset and prognosis of cardiovascular disease, fibrotic pulmonary disease, liver disease …

Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent
globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a …

Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …

The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop
malignant properties, while concerted interactions between cancer and stromal cells …

Expression of the immediate-early response gene IER2 has been associated with the
progression of several types of cancer, but its functional role is poorly understood. We found …