Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost
all or all organisms. Its synthetic pathway depends on the species in which it is measured …

Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Circadian organization of the mammalian transcriptome is achieved by rhythmic recruitment
of key modifiers of chromatin structure and transcriptional and translational processes …

The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …

BACKGROUND Research within the last decade has shown melatonin to have previously-
unsuspected beneficial actions on the peripheral reproductive organs. Likewise, numerous …

Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …