Despite maximal surgical and medical therapy, the treatment of glioblastoma remains a
seriously vexing problem, with median survival well under 2 years and few long-term …

Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed in part to a
population of self-renewing, therapeutically resistant cancer stem cells (CSCs) …

We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …

Glioblastomas are highly infiltrated by diverse immune cells, including microglia,
macrophages, and myeloid-derived suppressor cells (MDSCs). Understanding the …

Background We sought to ascertain the immune effector function of pembrolizumab within
the glioblastoma (GBM) microenvironment during the therapeutic window. Methods In an …

The invasiveness and high immune suppression of glioblastoma multiforme (GBM) produce
poor survival of afflicted patients. Unfortunately, in the past decades, no therapeutic …

Whereas the contribution of tumor microenvironment to the profound immune suppression of
glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 …

Endoplasmic reticulum (ER) stress has considerable impact on cell growth, proliferation,
metastasis, invasion, angiogenesis and chemoradiotherapy resistance in various cancers …

Effector CD8+ T cells are important mediators of adaptive immunity, and receptor-ligand
interactions that regulate their survival may have therapeutic potential. Here, we identified a …

Evidence is accumulating that the tumour microenvironment (TME) has a key role in the
progression of gliomas. Non-neoplastic cells in addition to the tumour cells are therefore …