Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal
end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia …

In this Primer, we focus on the most recent advancements in stimulated emission depletion
(STED) microscopy, encompassing optics, computational microscopy and probes design …

Primary cilia organize Hedgehog signaling and shape embryonic development, and their
dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

Highlights•Cell autonomous polarity, its transmission through division, are unifying themes
for centrosome/primary cilium functions.•Adhesion-dependent acto-myosin fibers play a …

Our understanding of motile cilia and their role in disease has increased tremendously over
the last two decades, with critical information and insight coming from the analysis of mouse …

CEP104 is an evolutionarily conserved centrosomal and ciliary tip protein. CEP104 loss-of-
function mutations are reported in patients with Joubert syndrome, but their function in the …

Multiciliated cells of the airways, brain ventricles, and female reproductive tract provide the
motive force for mucociliary clearance, cerebrospinal fluid circulation, and ovum transport …