Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …

Homeostasis of the gut microbiota critically influences host health and aging. Developing
genetically engineered probiotics holds great promise as a new therapeutic paradigm to …

Mitochondria participate in apoptosis through a range of mechanisms that vary between
vertebrates and invertebrates. In vertebrates, they release intermembrane space proteins …

Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …

Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

The single gene, single protein, single function hypothesis is increasingly becoming
obsolete. Numerous studies have demonstrated that individual proteins can moonlight …

Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative
phosphorylation (OXPHOS) to fuel its growth; however, broadly inhibiting this pathway might …

Mitochondria play central roles in integrating pro-and antiapoptotic stimuli, and JNK is well
known to have roles in activating apoptotic pathways. We establish a critical link between …

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the
behavior of mitochondria inside eukaryotic cells has changed dramatically, and the …