Organophosphorus (OP) nerve agents and pesticides inhibit acetylcholinesterase (AChE),
and this is thought to be a primary mechanism mediating the neurotoxicity of these …

Organophosphorus compounds (OP) are a constant problem, both in the military and in the
civilian field, not only in the form of acute poisoning but also for their long-lasting …

The design and the synthesis of prodrugs for nonsteroidal anti-inflammatory drugs (NSAIDs)
have been given much attention by medicinal chemists, especially in the last decade. As a …

There is compelling evidence that adverse neurobehavioral effects are associated with
occupational organophosphorous pesticide (OP) exposure in humans. Behavioral studies of …

The roles of proteolytic cleavage have been intensively investigated and discussed during
the past two decades. This irreversible chemical process has been frequently reported to …

Background Acute intoxication with organophosphorus (OP) cholinesterase inhibitors can
trigger convulsions that progress to life-threatening status epilepticus. Survivors face long …

Sulfur mustard (SM) is a bifunctional alkylating agent. Its primary toxic consequence is
severe skin damage with blisters, occurring after skin contact. These vesicant properties of …

Sulfur mustard (HD) is an alkylating and cytotoxic chemical warfare agent, which inflicts
severe skin toxicity and an inflammatory response. Effective medical countermeasures …

Mustard agents are potent DNA alkylating agents with mutagenic, cytotoxic and vesicant
properties. They include bi-functional agents, such as sulfur mustard (SM) or nitrogen …

Bifunctional alkyalating agent, sulfur mustard (SM)-induced cutaneous injury is
characterized by inflammation and delayed blistering. Our recent studies demonstrated that …