Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

COVID survivors frequently experience lingering neurological symptoms that resemble
cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial …

A major rate-limiting step in developing more effective immunotherapies for GBM is our
inadequate understanding of the cellular complexity and the molecular heterogeneity of …

Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and
ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet …

Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's
disease, but their roles in disease have not been tested experimentally. We find that in …

As the resident immune cells in the central nervous system (CNS), microglia orchestrate
immune responses and dynamically sculpt neural circuits in the CNS. Microglial dysfunction …

Although complex inflammatory-like alterations are observed around the amyloid plaques of
Alzheimer's disease (AD), little is known about the molecular changes and cellular …

Inflammatory processes and microglia activation accompany most of the pathophysiological
diseases in the central nervous system. It is proven that glial pathology precedes and even …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …