Regardless of purity and origin, therapeutic insulins continue to be immunogenic in humans.
However, severe immunological complications occur rarely, and less severe events affect a …

Insulin has been used for diabetes therapy and has achieved significant therapeutic effect.
In recent years, the use of purified and recombinant human insulin preparations has …

We describe the application of a stable isotope dilution assay (IDA) to determine precise
insulin, C-peptide, and proinsulin levels in blood by extraction from serum and quantitation …

Insulin levels in humans were measured by a new assay, the isotope dilution assay (IDA),
based on stable isotope dilution mass spectrometry. A known amount of a deuterated …

Metals contaminants of the environment from mine waste have been implicated as
contributing agents in autoimmune disease. The current study compares metals and …

The convenience of combining the measurement of antibodies to glutamic acid decru·
boxylase (GADA), protein tyrosine phosphatase (IA-2A), and autoantibodies to insulin (IAA) …

Autoantibodies against glutamic acid decarboxylase (GAD65) are present in the sera of
most patients with recently diagnosed insulin-dependent diabetes mellitus (IDDM). These …

Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the
immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 …

A new radioligand-binding assay (RBA) is described for the detection of insulin/proinsulin-
specific antibodies using 35S-labeled proinsulin produced by a cell-free reticulocyte extract …

Introduction Insulin and proinsulin autoantibodies (IAA/PAA) are usually the first markers to
appear in patients with type 1 Diabetes Mellitus (T1DM) and their prevalence ranges from 10 …