Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …

Referred to as the “guardian of the genome”, p53 is the most frequently mutated protein in
cancer and almost all cancers exhibit malfunction along the p53 pathway. As an …

Parkinson's disease (PD) is a neurodegenerative disease that devastatingly affects people's
lives. Numerous research studies have shown that peroxynitrite (ONOO–) plays a pivotal …

Cancer immunotherapy holds great promise but is generally limited by insufficient induction
of anticancer immune responses. In this work, Microcystis aerugiosa (MA) is observed to act …

Determining the properties of proteins prior to purification saves time and labor. Here, we
demonstrate a native mass spectrometry approach for rapid characterization of …

In vitro assays using reconstituted microtubules have provided molecular insights into the
principles of microtubule dynamics and the roles of microtubule-associated proteins …

Protein misfolding and aggregation contributes to the development of a wide range of
diseases. In cancer, over 50% of diagnoses are attributed to p53 malfunction due to …

A broad array of imaging and diagnostic technologies employs fluorophore-labeled
antibodies for biomarker visualization, an experimental technique known as …

Background: Aseptic loosening is the main reason for surgical revision after arthroplasty.
Although a series of mechanisms have been explored, a specific therapeutic target is still …

Small alterations during early stages of innate immune response can drive large changes in
how adaptive immune cells develop and function during protective immunity or disease …