Modular, multi-robot integration of laboratories: an autonomous workflow for solid-state chemistry

AM Lunt, H Fakhruldeen, G Pizzuto, L Longley… - Chemical …, 2024 - pubs.rsc.org
Automation can transform productivity in research activities that use liquid handling, such as
organic synthesis, but it has made less impact in materials laboratories, which require …

The ROY family's growing palette: Insights into recent compound additions and color range expansion-a short review

BA Nogueira, R Fausto - Journal of Molecular Structure, 2024 - Elsevier
Abstract The ROY (systematic name: 5-methyl-2-[(2-nitrophenyl) amino]-3-thiophene-
carbonitrile) molecule family stands as the most renowned group of color polymorphic …

Process Development for the First GMP Synthesis of SGD-9501-TFA, Part 2: Synthesis of the Payload, Linker, and Drug Linker

K Payne, JC Tran, B Gill, W Guy… - … Process Research & …, 2024 - ACS Publications
The discovery of novel auristatin-derived antibody drug conjugates (ADCs) with attenuated
bystander activity is an area of intense research. Recently, drug-linker SGD-9501-TFA …

Powder-Bot: A Modular Autonomous Multi-Robot Workflow for Powder X-Ray Diffraction

AM Lunt, H Fakhruldeen, G Pizzuto, L Longley… - arXiv preprint arXiv …, 2023 - arxiv.org
Powder X-ray diffraction (PXRD) is a key technique for the structural characterisation of solid-
state materials, but compared with tasks such as liquid handling, its end-to-end automation …

Unveiling the Red and Brownish-Green Polymorphs of a Novel ROY Derivative: 2-(4-((3-Cyanothiophen-2-yl) amino)-3-nitrophenyl) Acetic Acid

BA Nogueira, SMM Lopes, ACB Rodrigues… - Crystal Growth & …, 2024 - ACS Publications
Polymorphism has been the subject of many studies in the last decades, including a
particular type of polymorphism where the colors exhibited by the polymorphs differ …

Matching ROY crystal structures to high-throughput PXRD

GM Sparrow, RA Mayo, ER Johnson - CrystEngComm, 2024 - pubs.rsc.org
The ability of a compound to form different crystalline structures, possessing distinct
chemical and physical properties, is known as polymorphism. To identify the isolable …

Card fault diagnosis of the pressurized water reactor off-heap nuclear measurement system based on expert experience and convolutional neural network

P Jin, J Lu, Y Guan, P Zhu, Y Tian, W Zhu… - Journal of …, 2024 - iopscience.iop.org
The reactor nuclear measurement system is important in a nuclear power plant. Its main role
is to measure the reactor's core power distribution using detectors and calibrate and provide …

Structure Elucidation of Pharmaceutically Relevant Compounds within Pyrene‐based Frameworks

MT Chaudhry, JA Newman, AY Lee… - Chemistry–A European … - Wiley Online Library
Single crystal X‐ray diffraction (SCXRD) is the preferred and most accurate technique for
determining molecular structures. However, it can present challenges when dealing with …