Antimicrobial tolerance and metabolic adaptations in microbial biofilms

A Crabbé, PØ Jensen, T Bjarnsholt, T Coenye - Trends in microbiology, 2019 - cell.com
Active bacterial metabolism is a prerequisite for optimal activity of many classes of
antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic …

Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma?

MA Brown, M Jabeen, G Bharj… - European Respiratory …, 2022 - Eur Respiratory Soc
Asthma is a complex, heterogeneous condition that affects over 350 million people globally.
It is characterised by bronchial hyperreactivity and airways inflammation. A subset display …

Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

GL Monroy, J Won, DR Spillman Jr… - … of biomedical optics, 2017 - spiedigitallibrary.org
Since the inception of optical coherence tomography (OCT), advancements in imaging
system design and handheld probes have allowed for numerous advancements in disease …

Aerobic bacteria associated with chronic suppurative otitis media in Angola

F Uddén, M Filipe, Å Reimer, M Paul… - Infectious diseases of …, 2018 - Springer
Background Chronic suppurative otitis media (CSOM) is an important cause of hearing loss
in children and constitutes a serious health problem globally with a strong association to …

Otitis media: recent advances in otitis media vaccine development and model systems

A Zahid, JC Wilson, ID Grice, IR Peak - Frontiers in Microbiology, 2024 - frontiersin.org
Otitis media is an inflammatory disorder of the middle ear caused by airways-associated
bacterial or viral infections. It is one of the most common childhood infections as globally …

The unsolved problem of otitis media in indigenous populations: a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis …

A Coleman, A Wood, S Bialasiewicz, RS Ware… - Microbiome, 2018 - Springer
Background Otitis media (OM) imposes a great burden of disease in indigenous populations
around the world, despite a variety of treatment and prevention programs. Improved …

Topical therapy failure in chronic suppurative otitis media is due to persister cells in biofilms

PL Santa Maria, AC Kaufman, B Bacacao… - Otology & …, 2021 - journals.lww.com
Objective: Chronic suppurative otitis media (CSOM) is characterized by a chronically
draining middle ear. CSOM is typically treated with multiple courses of antibiotics or …

[HTML][HTML] Microbiology of chronic suppurative otitis media: an update from a tertiary care hospital in Bangladesh

MR Khatun, KMF Alam, M Naznin… - Pakistan journal of …, 2021 - ncbi.nlm.nih.gov
Objectives: Chronic suppurative otitis media is a major cause of acquired hearing
impairment, especially in children of developing countries. The study sought to explore the …

Direct analysis of pathogenic structures affixed to the tympanic membrane during chronic otitis media

GL Monroy, W Hong, P Khampang… - … –Head and Neck …, 2018 - journals.sagepub.com
Objective To characterize otitis media–associated structures affixed to the mucosal surface
of the tympanic membrane (TM) in vivo and in surgically recovered in vitro samples. Study …

Mapping of audiometric analysis with microbiological findings in patients with chronic suppurative otitis media (CSOM): a neglected clinical manifestation

S Dhingra, D Vir, J Bakshi, P Rishi - Critical Reviews in Clinical …, 2023 - Taylor & Francis
Otitis media (OM) is an umbrella term for a number of conditions associated with middle ear
inflammation. Chronic suppurative otitis media (CSOM), a type of OM, is characterized by …