Chromone: a valid scaffold in medicinal chemistry

A Gaspar, MJ Matos, J Garrido, E Uriarte… - Chemical …, 2014 - ACS Publications
Chromones are a group of naturally occurring compounds that are ubiquitous in nature,
especially in plants. The word chromone is derived from the Greek word chroma, meaning …

[HTML][HTML] Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression

T Nakanishi, DD Ross - Chinese journal of cancer, 2012 - ncbi.nlm.nih.gov
Breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …

[HTML][HTML] Human ABCG2: structure, function, and its role in multidrug resistance

W Mo, JT Zhang - … journal of biochemistry and molecular biology, 2012 - ncbi.nlm.nih.gov
Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …

A review on anticancer potentials of benzothiazole derivatives

N Pathak, E Rathi, N Kumar, SG Kini… - Mini reviews in …, 2020 - ingentaconnect.com
Benzothiazole is an organic compound bearing a heterocyclic nucleus (thiazole) which
imparts a broad spectrum of biological activities to it. The significant and potent activity of …

Development of inhibitors of ATP-binding cassette drug transporters–present status and challenges

S Shukla, CP Wu, SV Ambudkar - Expert opinion on drug …, 2008 - Taylor & Francis
Background: Multi-drug resistance (MDR) of cancer cells is an obstacle to effective
chemotherapy of cancer. The ATP-binding cassette (ABC) transporters, including P …

ABCG2: structure, function and role in drug response

O Polgar, RW Robey, SE Bates - Expert opinion on drug …, 2008 - Taylor & Francis
ABCG2 was discovered in multi-drug-resistant cancer cells, with the identification of
chemotherapeutic agents, such as mitoxantrone, flavopiridol, methotrexate and irinotecan as …

An update on natural occurrence and biological activity of chromones

SK Sharma, S Kumar, K Chand… - Current medicinal …, 2011 - ingentaconnect.com
The chemistry of chromones is very well known. This system is widely used in organic
chemistry as an intermediate compound for the synthesis of numerous hetrocycles. On the …

Synthesis, structure–activity relationship of novel substituted 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer …

BC Raju, RN Rao, P Suman, P Yogeeswari… - Bioorganic & Medicinal …, 2011 - Elsevier
Abstract Series of 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives 7a–
7zb, 8a–8d and 9a–9d were synthesized and screened for their in vitro anti-mycobacterial …

[HTML][HTML] Estrogen receptor ligands: a review (2013–2015)

S Farzaneh, A Zarghi - Scientia pharmaceutica, 2016 - mdpi.com
Estrogen receptors (ERs) are a group of compounds named for their importance in both
menstrual and estrous reproductive cycles. They are involved in the regulation of various …

[HTML][HTML] Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1, 2, 4-triazoles, 1, 2, 4-triazines and 1, 2, 4-triazepines ring systems

TES Ali, MA Ibrahim - Journal of the Brazilian Chemical Society, 2010 - SciELO Brasil
Three series of novel fused nitrogen heterocyclic systems such as 1, 2, 4-triazolo [1, 5-α]
pyridines (5-7 and 9), pyrido [1, 2-b][1, 2, 4] triazines (10, 11, 13 and 15), and pyrido [1, 2 …