CD4+ helper T (Th) cell subsets are critically involved in the pathogenesis of asthma. Naive
Th cells differentiate into different subsets under the stimulation of different sets of cytokines …

Objectives To investigate the landscape of TB cell interaction, immune receptor profiles and
effects of different types of immune responses in the involved tissues of IgG4-RD. Methods …

IL-4 and IL-13 play a critical role in allergic asthma pathogenesis via their common receptor
IL-4Rα. However, the cell-specific role of IL-4Rα in mixed allergen (MA)-induced allergic …

B cells can be polarized to express various cytokines. The roles of IFNγ and IL-10,
expressed respectively by B effector 1 (Be1) and Bregs, have been established in pathogen …

Background Eosinophils, basophils, and the molecule CD23 on B cells are involved in the
pathophysiology of atopic dermatitis (AD). The molecule CD23 is involved in the regulation …

IL-4 receptor α (IL-4Rα) has become a main target of allergic disease therapy since the
initial studies of blocking antibodies to IL-4Rα in mice over 20 years ago, yet which patients …

Introduction Current treatments for asthma help to alleviate clinical symptoms but do not cure
the disease. In this study, we explored a novel therapeutic approach for the treatment of …

Allergic asthma is a disease driven by T helper 2 (Th2) cells, eosinophilia, airway
hyperresponsiveness (AHR) and IgE-secreting B cells. Asthma is largely controlled by …

Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex
environmental and genetic predisposing factors. Primary skin barrier dysfunction and …

Despite ongoing efforts to eliminate malaria, Plasmodium infection remains a global health
burden with> 240 million clinical cases and> 620,000 deaths annually. Supporting …