The multifunctional protein HMGB1: 50 years of discovery
Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …
Targeting inflammation driven by HMGB1
High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell
types. It is a multi-facet protein exerting functions both inside and outside of cells …
types. It is a multi-facet protein exerting functions both inside and outside of cells …
RAGE and TLRs: relatives, friends or neighbours?
The innate immune system forms the first line of protection against infectious and non-
infectious tissue injury. Cells of the innate immune system detect pathogen-associated …
infectious tissue injury. Cells of the innate immune system detect pathogen-associated …
Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1–RAGE interaction
YU Okuma, K Liu, H Wake, R Liu, Y Nishimura, Z Hui… - …, 2014 - Elsevier
Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the
release of high mobility group box-1 (HMGB1), a protein considered representative of …
release of high mobility group box-1 (HMGB1), a protein considered representative of …
HMGB1: a double-edged sword and therapeutic target in the female reproductive system
Y Ren, D Zhu, X Han, Q Zhang, B Chen… - Frontiers in …, 2023 - frontiersin.org
HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin
associated transcription factor. It is present in the nucleus of eukaryotes and can be actively …
associated transcription factor. It is present in the nucleus of eukaryotes and can be actively …
Endogenous regulation and pharmacological modulation of sepsis-induced HMGB1 release and action: An updated review
CS Zhu, W Wang, X Qiang, W Chen, X Lan, J Li… - Cells, 2021 - mdpi.com
Sepsis remains a common cause of death in intensive care units, accounting for
approximately 20% of total deaths worldwide. Its pathogenesis is partly attributable to …
approximately 20% of total deaths worldwide. Its pathogenesis is partly attributable to …
[PDF][PDF] The importance of Ca2+/Zn2+ signaling S100 proteins and RAGE in translational medicine
E Leclerc, CW Heizmann - Front Biosci (Schol Ed), 2011 - article.imrpress.com
Introduction 3. General features of S100 proteins 4. The receptor for advanced glycation
endproducts (RAGE) 5. Structures and functions of S100 proteins and RAGE: association …
endproducts (RAGE) 5. Structures and functions of S100 proteins and RAGE: association …
Macrophage-derived HMGB1 as a pain mediator in the early stage of acute pancreatitis in mice: targeting RAGE and CXCL12/CXCR4 axis
Y Irie, M Tsubota, H Ishikura, F Sekiguchi… - Journal of Neuroimmune …, 2017 - Springer
Extracellular high mobility group box 1 (HMGB1) activates the receptor for advanced
glycation end products (RAGE) or Toll-like receptor 4 (TLR4) and forms a heterocomplex …
glycation end products (RAGE) or Toll-like receptor 4 (TLR4) and forms a heterocomplex …
Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats
T Nishida, M Tsubota, Y Kawaishi, H Yamanishi… - Toxicology, 2016 - Elsevier
Given that high mobility group box 1 (HMGB1), a nuclear protein, once released to the
extracellular space, promotes nociception, we asked if inactivation of HMGB1 prevents or …
extracellular space, promotes nociception, we asked if inactivation of HMGB1 prevents or …
The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1
HMGB1 is a chromatin architectural protein that is released by dead or damaged cells at
sites of tissue injury. Extracellular HMGB1 functions as a proinflammatory cytokine and …
sites of tissue injury. Extracellular HMGB1 functions as a proinflammatory cytokine and …