Current therapy of advanced cancers is based on several modalities including radiotherapy,
cytotoxic chemotherapy, molecularly targeted inhibitors and antibodies targeting immune …

Abstract Aloe vera (Aloe barbadensis Miller) is a perennial succulent medicinal plant. It has
been used as a traditional or folk medicine for thousands of years and claimed that it …

Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis
is tightly coordinated during bone development. However, the molecular regulators of …

Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical
processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine are widely used in the …

Objective Cardiovascular disease is the leading cause of death in breast cancer survivors.
While evidence shows circuit resistance training (CRT) is effective for improving muscle and …

Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular
endothelium (VE). The most principle mechanism might be excess reactive oxygen species …

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the
role of NO is decided by its concentration present in physiological environments. NO either …

Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic therapy (aSDT)
utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species …

Nitric oxide, carbon monoxide and hydrogen sulfide are three endogenous gasotransmitters
that serve a role in regulating normal and pathological cellular activities. They can stimulate …

Background: NOS3 (endothelial NOS, eNOS) is a member of the nitric oxide synthase (NOS)
enzyme family, mainly participating in nitric oxide (NO) generation. NOS3 has been reported …