The concept of allostery has become a central tenet in the study of biological systems. In
parallel, the discovery of allosteric drugs is generating new opportunities to selectively …

Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to
enzyme activity that substantially exceed the gains from individual mutations. Yet the …

Resistance to antibiotics is a public health crisis. Although carbapenems are less
susceptible to resistance than other β-lactam antibiotics, β-lactamases mediating resistance …

β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding
proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis. A …

Antibiotic resistance in bacteria is a major global health concern. The wide spread of
carbapenemases, bacterial enzymes that degrade the last-resort carbapenem antibiotics, is …

The fitness cost associated with antimicrobial resistance has an important influence on
evolutionary dynamics. We compared the genomes of three Klebsiella aerogenes isolates …

Objectives In this study, we discovered bla KPC-90 in ceftazidime-avibactam resistant
clinical isolates of K. pneumoniae from a patient with multiple comorbidities and investigated …

Objectives bla KPC-carrying Enterobacterales have post great challenges to global
healthcare systems. In this study, we reported the evolution and spread of bla KPC between …

Abstract β-lactams have been the most successful antibiotics, but the rise of multi-drug
resistant (MDR) bacteria threatens their effectiveness. Serine β-lactamases (SBLs), among …

Redundant carbapenemase-producing (RCP) bacteria, which carry double or multiple
carbapenemases, represent a new and concerning phenomenon. The objective of this study …