Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?

BC Baguley, LPG Wakelin, JD Jacintho… - Current medicinal …, 2003 - ingentaconnect.com
Reactive oxygen species (ROS) are produced continuously in living cells as a by-product of
respiration and other metabolic activity. Some ROS may react with DNA, and in some cases …

Two novel metal− organic frameworks (MOFs) with (3, 6)-connected net topologies: syntheses, crystal structures, third-order nonlinear optical and luminescent …

JP Zou, Q Peng, Z Wen, GS Zeng, QJ Xing… - Crystal growth & …, 2010 - ACS Publications
Two novel metal− organic frameworks (MOFs)[Cu3 (C7H2NO5) 2] n· 3 n H2O (1) and
[CuAg2 (C7H3NO5) 2] n (2) were obtained by the hydrothermal reaction. Complex 1 exhibits …

The binding of ethidium bromide with DNA: interaction with single-and double-stranded structures

PO Vardevanyan, AP Antonyan… - … & Molecular Medicine, 2003 - nature.com
The pH-induced helix-coil transition of DNA and its complexes with EtBr is carried out at
acidic pH in a wide interval of change of concentration ratio of EtBr/DNA. The binding …

The interaction of chalcones with tubulin

NJ Lawrence, AT McGown, S Ducki… - Anti-cancer drug …, 2000 - ingentaconnect.com
The chalcone 3, 4, 3′, 4′, 5′-pentamethoxychalcone is a potent cytotoxic agent. A series
of chalcones and (E)-4-(4′, 5′-pentamethoxychalcone is a potent cytotoxic agent. A series …

Crystal Structure of the Topoisomerase II Poison 9-Amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide Bound to the DNA Hexanucleotide d(CGTACG)2

A Adams, JM Guss, CA Collyer, WA Denny… - Biochemistry, 1999 - ACS Publications
The structure of the complex formed between d (CGTACG) 2 and the antitumor agent 9-
amino-[N-(2-dimethylamino) ethyl] acridine-4-carboxamide has been solved to a resolution …

Importance of polarization assisted/resonance assisted hydrogen bonding interactions and unconventional interactions in crystal formations of five new complexes …

M Mirzaei, H Eshtiagh-Hosseini, M Shamsipur… - RSC Advances, 2015 - pubs.rsc.org
(H4a-dmpy)[Cr (Hcda) 2]· 4H2O (1),(H2a-4, 6-dmpym)[Cr (Hcda) 2]· 3H2O· 2a-4, 6-dmpym
(2),[M (Hcda)(H2O) 3]· H2O (3) and (4)(M= CoII and NiII, respectively) and (H2a-4mpy) 2 …

Crystal engineering with coordination compounds of 2, 6-dicarboxy-4-hydroxypyridine and 9-aminoacridine fragments driven by different nature of the face-to-face π⋯ …

H Eshtiagh-Hosseini, M Mirzaei, S Zarghami… - …, 2014 - pubs.rsc.org
(H9a-Acr) 2 [Ni (hypydc) 2]· 4H2O (1),(H9a-Acr) 2 [Co (hypydc) 2]· 3H2O (2),(H9a-Acr)[Cr
(hypydc) 2]· 3H2O (3), and (H9a-Acr) 2 [Cd (hypydc) 2]· 3H2O (4) compounds (H2hypydc= 2 …

Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers

NJ Lawrence, D Rennison, M Woo, AT McGown… - Bioorganic & medicinal …, 2001 - Elsevier
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was
prepared and evaluated for anticancer activity. 2-Methoxy-5-(3′, 4′, 5 …

Recognition of duplex RNA by helix-threading peptides

BD Gooch, PA Beal - Journal of the American Chemical Society, 2004 - ACS Publications
Many important biological processes, from the interferon antiviral response to the generation
of microRNA regulators of translation, involve duplex RNA. Small molecules capable of …

An experimental and theoretical approach of spectroscopic and structural properties of a new chelidamate copper (II) complex

H Vural, I Ucar, MS Soylu - Spectrochimica Acta Part A: Molecular and …, 2014 - Elsevier
The crystal structure of new chelidamate complex of copper (II) ion,[Cu (chel) H 2 O (pym)]· H
2 O [chel: chelidamate or 4-hydroxypyridine-2, 6-dicarboxylate; pym: 2-Pyridylmethanol] has …