Neuronal computation is energetically expensive. Consequently, the brain's limited energy
supply imposes constraints on its information processing capability. Most brain energy is …

Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …

Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Cell types rich in mitochondria, including neurons, display a high energy demand and a
need for calcium buffering. The importance of mitochondria for proper neuronal function is …

The calyx of Held is an axosomatic terminal in the auditory brainstem that has attracted
anatomists because of its giant size and physiologists because of its accessibility to patch …

We hypothesized that dysregulation of lactate/pyruvate (monocarboxylate) transporters
(MCT) and lactate dehydrogenase (LDH) isoforms contribute to the Warburg effect in cancer …

Synapses are the key elements for signal processing and plasticity in the brain. To
determine the structural factors underlying the unique functional properties of the …

To evaluate the presence of components of a putative Intracellular Lactate Shuttle (ILS) in
neurons, we attempted to determine if monocarboxylate (eg lactate) transporter isoforms …

The calyx of Held is a large glutamatergic synapse in the mammalian auditory brainstem. By
using brain slice preparations, direct patch-clamp recordings can be made from the nerve …

Abstract Synaptotagmin 1 and 2 (syt 1, syt 2) are synaptic vesicle‐associated membrane
proteins that act as calcium sensors for fast neurotransmitter release from presynaptic nerve …