Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

SLIT ligand and its receptor ROBO were initially recognized for their role in axon guidance in
central nervous system development. In recent years, as research has advanced, the role of …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C ([C@ H](NC (=
O)[C@ H](C (C) C) NC (= O) CNC (= O)[C@ H](CCC (O)= O) NC (= O)[C@ H](CCCNC (N) …

Background Non-muscle-invasive bladder cancer (NMIBC) is a high incidence form of
bladder cancer (BCa), where genetic and epigenetic alterations occur frequently. We …

Abstract Slit homolog 2 (Slit2) is distributed in various tissues and participates in numerous
cellular processes; however, the role of Slit2 in the regulation of angiogenesis remains …

Brain metastasis is a significant unmet clinical problem in breast cancer treatment. It is
always associated with poor prognosis and high morbidity. Recently, Slit2/Robo1 pathway …

Slit and Robo are considered tumor suppressors because they are frequently inactivated in
various tumor tissue. These genes are closely correlated with CpG hypermethylation in their …

Objectives Mechanisms that regulate proliferation of adult neural stem cells are largely
unknown. Here, we have investigated the role of microR‐30c (miR‐30c) and its target …

The neural guidance molecular, Slit2, and its cognate receptor, Robo1, play critical roles in
the development of the nervous system, nevertheless, their functions are not limited to this …