Additive manufacturing in drug delivery: Innovative drug product design and opportunities for industrial application

H Ragelle, S Rahimian, EA Guzzi… - Advanced Drug Delivery …, 2021 - Elsevier
Additive manufacturing (AM) or 3D printing is enabling new directions in product design. The
adoption of AM in various industrial sectors has led to major transformations. Similarly, AM …

Continuous manufacturing in pharmaceutical process development and manufacturing

CL Burcham, AJ Florence… - Annual review of …, 2018 - annualreviews.org
The pharmaceutical industry has found new applications for the use of continuous
processing for the manufacture of new therapies currently in development. The …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Recent progress in continuous manufacturing of oral solid dosage forms

V Vanhoorne, C Vervaet - International Journal of Pharmaceutics, 2020 - Elsevier
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …

A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

L Rolinger, M Ruedt, J Hubbuch - Analytical and bioanalytical chemistry, 2020 - Springer
As competition in the biopharmaceutical market gets keener due to the market entry of
biosimilars, process analytical technologies (PATs) play an important role for process …

Review of real-time release testing of pharmaceutical tablets: State-of-the art, challenges and future perspective

D Markl, M Warman, M Dumarey, EL Bergman… - International journal of …, 2020 - Elsevier
In the last decade significant advances have been made in process analytical technologies
and digital manufacturing of pharmaceutical oral solid dosage forms leading to enhanced …

A review of current techniques for the evaluation of powder mixing

M Asachi, E Nourafkan, A Hassanpour - Advanced Powder Technology, 2018 - Elsevier
Blending a mixture of powders to a homogeneous system is a crucial step in many
manufacturing processes. To achieve a high quality of the end product, powder mixtures …

Detailed modeling and process design of an advanced continuous powder mixer

P Toson, E Siegmann, M Trogrlic, H Kureck… - International Journal of …, 2018 - Elsevier
A vertical in-line continuous powder mixing device (CMT–Continuous Mixing Technology)
has been modelled with the discrete element method (DEM) utilizing a calibrated cohesive …

PAT implementation for advanced process control in solid dosage manufacturing–A practical guide

S Sacher, J Poms, J Rehrl, JG Khinast - International Journal of …, 2022 - Elsevier
The implementation of continuous pharmaceutical manufacturing requires advanced control
strategies rather than traditional end product testing or an operation within a small range of …

Hot-melt extrusion: from theory to application in pharmaceutical formulation—where are we now?

H Patil, SK Vemula, S Narala, P Lakkala… - AAPS …, 2024 - Springer
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …