The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Actin‐binding proteins (ABPs), by interacting with actin, regulate the polymerization,
depolymerization, bundling, and cross‐linking of actin filaments, directly or indirectly …

Somite formation is foundational to creating the vertebrate segmental body plan. Here, we
describe three transcriptional trajectories toward somite formation in the early mouse …

Intratumoral T cells that might otherwise control tumors are often identified in an “exhausted”
state, defined by specific epigenetic modifications and upregulation of genes such as CD38 …

Transforming growth factor β (TGFβ) signaling plays an important role in regulating tumor
malignancy, including in non–small cell lung cancer (NSCLC). The major biological …

Regulatory T cells (Tregs) are indispensable for the control of immune homeostasis and
have clinical potential as a cell therapy for treating autoimmunity. Tregs can lose expression …

The transcriptional and epigenetic regulation of CD8+ T cell differentiation is critical for
balancing pathogen eradication and long-term immunity by effector and memory CTLs …

Abstract Background As an H3K27me3 demethylase and counteracts polycomb-mediated
transcription repression, KDM6B has been implicated in the development and malignant …

Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a
distant organ often undergo anoikis's specialized form of apoptosis. Recently, KDM3A …

Histone H3K27me3 demethylase KDM6B (also known as Jumonji domain-containing
protein D3, JMJD3) plays vital roles in the etiology of inflammatory responses; however, little …